Beyond these insights there are further applications and future challenges

Beyond these insights there are further applications and future challenges.

Beyond these insights there are further applications and future challenges Sir, Insights into the genetic susceptibility to Crohn's disease (CD) 1 would be incomplete without recognition that the unrivalled success of azathioprine in inducing and maintaining remission in corticoster-oid-dependent CD 2 ought to go hand in hand with a wider application of pharmacogenetic testing 3 so as to optimi...

Chronic Endometritis: Old Problem, Novel Insights and Future Challenges

Background/Aims: Chronic endometritis (CE) is a poorly investigated pathology that has been related to adverse reproductive outcomes, such as implantation failure and recurrent miscarriage. In this paper we aim to provide an overview about diagnosis, etiology, pathophysiology and treatment of CE, its impact on endometrial microenvironment and how it may be associated with infertility. Methods: ...

Genetics and the general physician: insights, applications and future challenges

Scientific and technological advances in our understanding of the nature and consequences of human genetic variation are now allowing genetic determinants of susceptibility to common multifactorial diseases to be defined, as well as our individual response to therapy. I review how genome-wide association studies are robustly identifying new disease susceptibility loci, providing insights into d...

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

P30: Are There Anxious Genes?

Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. Complete genome-wide linkage s...